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抽象的
背景和目的：依赖型巨型细胞肿瘤和依赖型膜结节的生长尚未得到充分的特征。这项研究的目的是确定生长曲线是否可以将亚依赖型巨细胞肿瘤与亚依赖型结节区分开。
材料和方法:Brain MR imaging of patients with tuberous sclerosis complex were retrospectively reviewed from 2002 to 2018. All lesions in the region of the foramen of Monro were measured. Lesions were categorized on the basis of maximal diameter at the most recent scan: small lesions (<1 cm), indeterminate lesions (>1 cm), and resected lesions (>1 cm and surgically resected). Growth velocity and acceleration on serial imaging were analyzed, and growth rates were calculated between 0 and 20 years of age and compared among the 3 categories.
结果：Forty-one patients were analyzed. The average age at the earliest scan was 5.9 (SD = 5.7) years. One hundred twenty-six small, 27 indeterminate, and 10 resected lesions were measured. Subependymal giant cell tumors grew faster than indeterminate lesions between 6 and 15 years of age. Indeterminate lesions grew faster than small lesions at 0–10 years of age. Resected lesions showed increased velocity and acceleration of growth compared with indeterminate lesions and small lesions on serial imaging.
结论：Growth differentiates subependymal nodules and subependymal giant cell tumors within the first 20 years of life, and the use of velocity and acceleration of growth may refine the diagnostic criteria of subependymal giant cell tumors. Additionally, 6–15 years of age may be an important period to monitor subependymal giant cell tumors at the foramen of Monro because increased growth may help to identify subependymal giant cell tumors that will continue to grow and result in obstructive hydrocephalus.
ABBREVIATIONS:
- AP
- anterior-posterior
- FOM
- 门罗的孔
- IQR
- 四分位数范围
- SEGA
- 依赖型巨细胞星形胶质细胞瘤
- SEN
- subependymal nodule
- SGCT
- subependymal giant cell tumor
- SI
- superior-inferior
- TSC
- 结节硬化症复合物
- TV
- transverse
- © 2021 by American Journal of Neuroradiology
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